![]() Avoid in hepatic coma if risk of renal failure. Hepatic Dose : No dosage adjustments are recommended. Diplopia, urticarial rash Interaction :Īmikacin, Tobramycin, Neomycin, Netilmicin, Kanamycin, Streptomycin, Gentamycin, Calcitriol.Ītracurium, Botulinum toxin, Cisatracurium, Edrophonium, Neostigmine, Nifedipine, Pancuronium, Pyridostigmine, Rocuronium, Vecuronium. According to Wirtz, taking magnesium supplements can also cause magnesium toxicity, which in turn can 'result in various side effects such as low blood pressure, vomiting, retention of urine, depression, and muscle weaknesses. Asystole has occurred at levels above 25 mEq/L. Bradyarrhythmia’s have occurred at levels above 10 mEq/L. Cardiovascular side effects of magnesium are due to vasodilation, leading to flushing, chest pain and palpitations with rapid infusions and hypotension at serum levels of 7 to 10 mEq/L. Gastrointestinal side effects have included primarily diarrhea, nausea (Mg levels of 4 to 5 mEq/L), and rare cases of paralytic ileus (Mg levels greater than 5 mEq/L). Death may occur at any serum level but has been especially common at levels above 15 mEq/L. Magnesium has also been reported to have a curare-like effect at the neuromuscular junction at serum levels above 10 mEq/L. At levels of 10 to 15 mEq/L, profound mental depression, areflexia, coma and respiratory paralysis has been a common occurrence. At levels of 7 to 10 mEq/L, slower respiratory rates and decreased blood pressure has been reported. Clinically, serum levels above 4 to 7 mEq/L have led to decreased deep tendon reflexes, muscle weakness, mental confusion or sedation. Tell your doctor if symptoms of low magnesium blood levels (such as muscle cramps, tiredness, irritability, depression) last or get. Nervous system side effects from hypermagnesemia result from suppression of neuromuscular transmission in the CNS and at the neuromuscular junction by magnesium. Too much magnesium in the blood can cause serious side effects. Electrocardiograph changes with a magnesium sulfate overdose have included increased QRS complex width, increased PR interval, and prolonged QT interval. ![]() Adverse Effect :įlushing, hypothermia, sweating, sharply lowered blood pressure, stupor, CNS depression with depressed reflexes and disorientation, dilated pupils and ultimately, respiratory depression. 100 mg/kg IM every 4-6 hours, as needed, or 20-40 mg/kg IM as needed.
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